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myriocin, an inhibitor of serine palmitoyl-transferase (spt), a key enzyme for ceramide de novo synthesis  (Cayman Chemical)


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    Cayman Chemical myriocin, an inhibitor of serine palmitoyl-transferase (spt), a key enzyme for ceramide de novo synthesis
    Myriocin, An Inhibitor Of Serine Palmitoyl Transferase (Spt), A Key Enzyme For Ceramide De Novo Synthesis, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ceramide+synthesis+inhibitors/pmc10054354-116-13-27?v=Cayman+Chemical
    Average 90 stars, based on 1 article reviews
    myriocin, an inhibitor of serine palmitoyl-transferase (spt), a key enzyme for ceramide de novo synthesis - by Bioz Stars, 2026-08
    90/100 stars

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    ERBB2-positive cells' sensitivity to palmitate is through ROS formation and ceramide production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor fumonisin B1 for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.

    Journal: Breast Cancer Research : BCR

    Article Title: Peroxisome proliferator-activated receptor-γ protects ERBB2-positive breast cancer cells from palmitate toxicity

    doi: 10.1186/bcr2240

    Figure Lengend Snippet: ERBB2-positive cells' sensitivity to palmitate is through ROS formation and ceramide production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor fumonisin B1 for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.

    Article Snippet: The PPARγ antagonist GW9662, the fatty acid palmitate, and the ceramide synthesis inhibitor fumonisin B1 were obtained from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Standard Deviation